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It has been proposed that the GCGR ECD stays in close contact with the TMD in the apo state to inhibit the receptor activation [24] (model in Figure 9a)

So, cysteinylated proteins taken up from the plasma by micropinocytosis can constitute a source of cysteine that once in the cell will be used in the different cysteine metabolic pathways, even in the s -cysteinylation of other proteins